Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1
نویسندگان
چکیده
منابع مشابه
Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1.
CDX1 is a transcription factor that plays a key role in intestinal development and differentiation. However, the downstream targets of CDX1 are less well defined than those of its close homologue, CDX2. We report here the identification of downstream targets of CDX1 using microarray gene-expression analysis and other approaches. Keratin 20 (KRT20), a member of the intermediate filament and a we...
متن کاملVascular Endothelial Growth Factor Production is Regulated by Gene Polymorphisms
Background: Vascular endothelial growth factor (VEGF) has a key role in angiogene-sis and in transplantation. The level of VEGF is related to the differences in the DNA sequence of its promoter region. Objectives: In this study, the association between the combination of VEGF –1154 G and –2578 C alleles and VEGF production by LPS-stimulated PBMCs was investigated. In addition; the relationship ...
متن کاملNk6, a novel Drosophila homeobox gene regulated by vnd
Nk(x)-type homeobox genes are an evolutionarily conserved family that regulate diverse developmental processes. Here we describe a novel Drosophila gene, Nk6, which encodes an Nk-type transcription factor most homologous to vertebrate Nkx6.1 and Nkx6.2. The homeodomains and NK decapeptide domains of all three proteins are highly conserved. Nk6 is expressed in the embryonic brain, ventral nerve ...
متن کاملCytokeratin polypeptide in gastrointestinal adenocarcinomas displaying squamous differentiation.
In the present study we investigated the cytokeratin (CK) polypeptide expression in gastric and colonic adenocarcinomas. A battery of monoclonal anti-cytokeratin-specific antibodies and anti-vimentin were used. While the majority of cases displayed simple epithelial characteristics, in three of 17 cases of gastric adenocarcinomas and in one of 20 cases of colonic adenocarcinomas, CK polypeptide...
متن کاملvascular endothelial growth factor production is regulated by gene polymorphisms
background: vascular endothelial growth factor (vegf) has a key role in angiogene-sis and in transplantation. the level of vegf is related to the differences in the dna sequence of its promoter region. objectives: in this study, the association between the combination of vegf –1154 g and –2578 c alleles and vegf production by lps-stimulated pbmcs was investigated. in addition; the relationship ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2009
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0812904106